Multiple choice

A cell cultured in colchicines undergoes a complete cell cycle, except for the fact that chromosomes donot migrate to the poles during anaphase. What can be concluded from this?

  1. Colchicines do not affect the microtubules.

  2. DNA replication does not necessarily results in the chromosome separation.

  3. Centromere represent under replicated DNA.

  4. Spindle is made after interphase.
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

Colchicine inhibits microtubule polymerization, preventing spindle fiber formation during mitosis. Since chromosomes cannot attach to spindle fibers, they fail to separate and migrate to opposite poles during anaphase. DNA replication occurs normally in S phase, but chromosome segregation cannot complete without functional microtubules.

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