Which of the following statements about the Bursa of fabricius (BOF) is correct?
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BOF is responsible for human immunity and not for chicken's immunity towards the bacterial infection.
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BOF is a vital element of the chicken's immune system, while having no effect on the human systems.
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BOF is a vital element of the chicken's immune system, although it helps in enhancement of human immune response too.
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BOF is responsible for chicken immunity and not for human immunity towards the viral infection.
BOF is present in birds near cloaca, and is the site of B-cell production and maturation. While in humans it is absent, its function is performed by bone marrow. Removal of BOF in birds will be fatal in case of infections while humans will not be affected. In due course of evolution, humans adapted to bone marrow instead of BOF, but both avian and human B cells are the same. Therefore, BOF in humans will also be a site of B-Cell development and thus, the human immune system will be enhanced. The answer 2 can also be considered to be correct, as the current research supports the 3 answer but books still believe in 2.