Multiple choice

Splicing is a post transcriptional modification in which newly transcribed hetero nuclear RNA is modified into mRNA. Faulty splicing can cause diseases in any organism. Identify the way by which faulty splicing can cause thalasemia in humans.

  1. Malformation of α chain of haemoglobin leads to α thalassemia.

  2. Malformation of β chain of haemoglobin leads to β thalassemia.

  3. Malformation of one α and one β chains of haemoglobin causes α β major thalassemia.

  4. Malformation of both α and β chains of haemoglobin causes α β major thalassemia.

  5. α chains have less amino acids.
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B Correct answer
Explanation

This is due to the mutation that results in a nucleotide change at an exon-intron junction, which leads to lack of synthesis of β chain of haemoglobin and consequently the disease β thalassemia occurs to the human being.

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