Multiple choice

What is the role of viral infectivity factor?

  1. Regulating nuclear import

  2. Disruption of enzyme APOBEC

  3. Establishment of infection

  4. Cleaving newly synthesized polyproteins
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B Correct answer
Explanation

Viral infectivity factor (vif)'s role is to disrupt the antiviral activity of the human enzyme APOBEC by targeting it for ubiquitination and cellular degradation. APOBEC is a cytidine deaminase enzyme that mutates viral nucleic acids.

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