Multiple choice

Which type of mutation can make the purine nucleotides to be depurinated?

  1. Transition mutation

  2. Transversion mutation

  3. Neutral mutation

  4. Spontaneous mutation

  5. Frameshift mutation

Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

This type of mutation is originated from lesions in DNA as well as from replication errors. For example it is possible for purine nucleotide to be depurinated that is to lose their base. This results in the formation of an apurinic site which will not base pair normally and may cause transition type mutation after the next round of replication. Cytosine can be deaminated to uracil which is then removed to form an apyrimidinic site.