Which of the following amino acids get replaced by valine amino acid in sickle cell anemia patients?
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Histidine
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Lysine
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Cysteine
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Glutamic acid
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Aspartic acid
D
Correct answer
Explanation
A single nucleotide pair alteration is the cause of sickle cell anemia: the template strand of mutated sickle cell DNA has an A rather than a T. U takes the place of A in the mRNA. A valine amino acid is made in the sickle cell haemoglobin instead of a glutamic acid. GAG which codes for the amino acid glutamic acid is changed to GTG for valine as a result of the mutation in the position of second nucleotide of the codon GAG.