Multiple choice Why are frame-shift mutations more mutating than base substitutions? Frameshifts are less common than base substitutions. More than one amino acid are affected by frameshift. More than one amino acid are affected by base substitutions. Only one amino acid is affected by frameshift. Reveal answer Fill a bubble to check yourself B Correct answer Explanation Frameshift mutation affects more than one amino acid. Due to the triplet nature of gene expression by codons, the insertion or deletion can change the reading frame resulting in a completely different translation from the original.