Multiple choice

Which among the following is caused by mutation in OPN1LW and OPN1MW genes?

  1. Red-Green colour blindness

  2. Hereditary deafness

  3. Tyrosinemia

  4. Galactosemia
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A Correct answer
Explanation

It is a X-linked recessive disease. It is caused by mutation in OPN1LW and OPN1MW, encoding red and green sensitive opsins. These genes are clustered on the X chromosome, with one red pigment gene followed by 1-6 green pigment genes. Unequal crossover events between these genes lead to creation of non-expressed hybrid genes and deletions.

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