Multiple choice

Which of the following is an autoimmune condition with the single most profound genetic association?

  1. Graves' disease

  2. Type1 diabetes

  3. Ankylosing spondylitis

  4. Rheumatoid arthritis

  5. IPEX (Immune dysregulation, polyendocrinopathy, enteropathy and X-linked syndrome)
Reveal answer Fill a bubble to check yourself
E Correct answer
Explanation

By far, the vast majority of autoimmune diseases involve multiple genes together with environmental factors. IPEX is an example of an extremely small number of autoimmune diseases that are caused by a single gene defect. In this case, mutation of the Foxp3 gene results in a profound defect in regulatory T-cell activity.

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