Multiple choice

Which of the following types of mutation would not be expected to detect in a molecular diagnostic test which is based on sequencing each exon of a gene in genomic DNA from a male suspected of having a X-linked disorder?

  1. Missense mutation

  2. Nonsense mutation

  3. Deletion of an exon

  4. Inversion of part of the gene
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

An inversion of part of the gene would not cause the exons to be absent or missing, and the sequencing reaction would not reveal that the exons are no longer arranged in the proper order on genomic DNA.

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