Multiple choice

Chronic granulomatous disease is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. Which of the following is the primary defect in chronic granulomatous disease (CGD)?

  1. Neutrophil production in the bone marrow

  2. Neutrophil chemotaxis

  3. Neutrophil intracellular killing of organisms

  4. Opsonisation

  5. Cytotoxic T-cell activity
Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

Neutrophils from patients with CGD fail to produce super-oxide that enables an influx of potassium ions to activate the intracellular enzymes that kill organisms.

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