Multiple choice

Autoantigen selection of responding B-cells during tumor formation in the body is indicated by

  1. germ line configuration of the antibody

  2. high affinity antibody

  3. expression of a public idiotype

  4. a monoclonal antibody response

  5. a response to many different autoantigens
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

The mutation of the antibody variable region genes in B-cells in the germinal center produces a range of antibody affinities, and those B-cells bearing higher affinity antibody will be favourably selected for further stimulation by antigen.

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