Multiple choice

Which among the following statements regarding SCID is false?

  1. Most cases of SCID are due to mutations in the gene encoding the common gamma chain.

  2. The condition is inherited in an X-linked dominant pattern.

  3. The second most common form of SCID is caused by a defective enzyme.

  4. PNP is a key enzyme in the purine salvage pathway.

  5. The most common treatment for SCID is bone marrow transplantation.
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

The common gamma chain is encoded by the gene IL-2 receptor gamma, or IL-2Rγ, which is located on the X-chromosome. For this reason, immunodeficiency caused by mutations in IL-2Rγ is known as X-linked severe combined immunodeficiency. The condition is inherited in an X-linked recessive pattern.

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