Which one of the following statements is correct with regard to the principle of safe blood transfusion?
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The recipient's serum should not contain antigens against the donor's antibodies.
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The donor's red blood corpuscles should not contain antibodies against the recipient's serum.
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The recipient's red blood corpuscles should not contain antibodies against the donor's antigen.
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The recipient's serum should not contain the antibodies against the red blood corpuscles of the donor.
Blood transfusion is generally the process of receiving blood into one's circulation intravenously. Antigens are present on the surface of red blood corpuscles, while antibodies are present in the plasma of the blood, for e.g., people with blood group A have surface antigen A on their RBC's and antibodies to antigen B in their plasma. So, when RBC's are donated, transfer of antibodies doesn't take place. But as the RBC's of the donor have a surface antigen, it should be ensured that recipient's serum should not contain antibodies against the antigen on red blood corpuscles of the donor. Otherwise, if transfusion is made between incompatible donor and recipient, the reaction between antigens on the RBC (from the donor) and antibodies in the plasma (of the recipient) will produce clots and clog capillaries. Thus, the correct answer is option D.