EDTA injected into muscles combines with $Ca^{2+}$ and
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Stops contraction
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Causes contraction
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Slows down contraction
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None of the above
Reveal answer
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C
Correct answer
Explanation
- Active sites for myosin are present on actin which are masked by troponin in resting state. When Ca++ level increases it leads to the binding of calcium with a subunit of troponin on actin(thin) filaments and thereby remove the masking of active sites for myosin.
- Utilizing the energy from ATP hydrolysis, the myosin head now binds to the exposed active sites on actin to form a cross bridge.
- This pulls the attached actin filaments towards the centre of ‘A’ band.
- The ‘Z’ line attached to these actins are also pulled inwards thereby causing a shortening of the sarcomere, i.e., contraction.
- When EDTA injected into muscles combines with Ca ++ and prevents the binding of calcium with troponin and slows down contraction.
- So, the correct answer is 'Slows down contraction'.