In a resting muscle fibre, tropomyosin partially covers
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Ca-binding sites on actin
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Ca-binding sites on troponin
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Actin binding sites on myosin
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Myosin binding sites on actin
Reveal answer
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Correct answer
Explanation
- The myofibril is composed of two types of filaments. They are thick filament (Myosin) and Thin filament (Actin).
- Each actin (thin) filament is made of two ‘F’ (filamentous) actins helically wound to each other. Each ‘F’ actin is a polymer of monomeric ‘G’ (Globular) actins. Two filaments of another protein, tropomyosin also run close to the ‘F’ actins throughout its length. A complex protein Troponin is distributed at regular intervals on the tropomyosin. In the resting state tropomyosin partially covers myosin binding site on actin.
- Increase in Ca++ level leads to the binding of calcium with a subunit of troponin i.e troponin-C on actin filaments and thereby remove the masking of active sites for myosin. Utilizing the energy from ATP hydrolysis, the myosin head now binds to the exposed active sites on actin to form a cross bridge.
- Hence In a resting muscle fibre, tropomyosin partially covers myosin binding sites on actin.
- So, the correct answer is 'Myosin binding sites on actin'.