Biology

Human Genetics and Disorders

844 Questions

Human Genetics and Disorders covers the inheritance patterns, genetic mutations, and molecular basis of hereditary diseases. Topics include sex-linked traits, cancer genetics, and metabolic disorders. This section tests knowledge critical for biology exams and general science papers.

Genetic mutationsInherited disordersCancer geneticsGenetic testingMendelian inheritance

Human Genetics and Disorders Questions

Multiple choice

Which of the following is a sex-linked disease?

  1. Sickle cell anaemia

  2. Phenylketonuria

  3. Albinism

  4. Haemophilia

  5. -
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

It is the mostly inherited and genetic disorder that impairs the body's ability to form blood clots, a process needed to stop bleeding when a blood vessel is broken.

Multiple choice

Which of the following is/are sex linked disease(s)?

  1. Haemophilia

  2. Colour blindness

  3. Both 1 and 2

  4. Syphlis
Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

Sex-linked genetic disorders are conditions that are caused by a defective gene on the X chromosome, one of the sex chromosomes. These disorders may also involve a deviation in the number of X or Y chromosomes, such as haemophilia and colour blindness.

Multiple choice

Which of the following genetic disorders is a sex linked disease?

  1. Sickle-cell anemia

  2. Haemophilia

  3. Cystic fibrosis

  4. Tay-Sachs disease

  5. Huntington’s disease
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

Haemophilia is a hereditary bleeding disorder in which there is a partial or total lack of an essential blood clotting factor. It is a lifelong disorder  that results in excessive bleeding. Due to the sex-linkage of the disorder, there is a greater prominence in males than in females.

Multiple choice

The Huntington's disease mutation is genetically dominant, because either of a person's HTT genes being mutated causes the disease. CAG/CTG repeat expansions at the Huntington's disease is associated with which of the following genes?

  1. JPH3 gene

  2. ACSF3 gene

  3. ACD gene

  4. AMFR gene

  5. CYLD gene
Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

CAG/CTG repeat expansions at the Huntington's disease (HD)-like 2 locus have been identified in this gene, which is a member of the junctophilin gene family.

Multiple choice

Which of the following types of mutations is most likely to result from UV exposure?

  1. Thymidine dimer

  2. Chromosome breakage

  3. Frameshift mutation

  4. Nonsense mutations

  5. Chromosome inversion
Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

UV exposure leads to thymidine dimers. Thymidine dimer are molecular lesions formed from thymine or cytosine bases in DNA via photochemical reactions. Ultraviolet light induces the formation of covalent linkages by reactions localised on the C=C double bonds.