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Purine Metabolism: Exploring the Pathways for Synthesizing and Degrading Purines

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Which enzyme catalyzes the rate-limiting step in de novo purine biosynthesis?

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A
Phosphoribosyl pyrophosphate amidotransferase (PPAT)
💡 Explanation:

PPAT catalyzes the first step in de novo purine biosynthesis, which is the conversion of phosphoribosyl pyrophosphate (PRPP) to 5-phosphoribosyl-1-amine (PRA).

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