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Genetics and Molecular Biology

A test covering genetics topics including chromosomal disorders, DNA replication, blood group systems, and genomic imprinting.

25 Questions Published
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Questions

Question 1 Multiple Choice (Single Answer)

All of the following karyotypes are found in spontaneous abortuses. Which of the following is least likely to be found in a live-born infant?

  1. 46,XY
  2. 45, X
  3. 47, XX,+21
  4. 47, XX,+16
Question 2 Multiple Choice (Single Answer)

In which of the following phenotypic females does a pair of testis originate?

  1. 46, XY with X-linked androgen receptor inadequacy
  2. 45, X
  3. 46, XY with a point mutation in the HMG arena of the SRY gene.
  4. 46, XY with an interstitial deletion of Yp including the SRY gene.
Question 3 Multiple Choice (Single Answer)

A 30-year-old lady whose father is a suffer of Huntington disease requests genetic testing to determine if he has inherited the mutation. He is so far asymptomatic. She should be counseled

  1. At 30 years of age, she would already have shown symptoms if she had inherited the mutation.
  2. She faces a 50-50 risk of developing symptoms of Huntington disease.
  3. She remains at risk at age 30, though his risk is less than 50% being asymptomatic at this age.
  4. The fact that her father was the affected individual, which indicates that he must not have inherited the gene, since paternally-transmitted Huntington disease has onset in childhood.
Question 4 Multiple Choice (Single Answer)

Among the following human diseases which is feeblest caused by aneuploidy?

  1. Turner syndrome
  2. Fragile X syndrome
  3. Down syndrome
  4. Klinefelter syndrome
Question 5 Multiple Choice (Single Answer)

Which enzyme is responsible for unwinding DNA during replication?

  1. DNA polymerase
  2. Ligase
  3. Helicase
  4. Lipase
Question 6 Multiple Choice (Single Answer)

Which of the following statements regarding the lagging strand during DNA replication is FALSE?

  1. It is synthesized by DNA polymerase δ.
  2. It is synthesized in Okazaki fragments.
  3. Its synthesis involves RNA polymerase.
  4. Its synthesis involves the enzyme telomerase.
Question 7 Multiple Choice (Single Answer)

Which of the following characteristics differentiates DNA from RNA?

  1. Occurence of 3' deoxyribose in DNA, ribose in RNA.
  2. Occurence of uracil in RNA instead of thymidine in DNA.
  3. Existence of base pairing in DNA but not RNA.
  4. Existence of 5' phosphate in DNA but not RNA.
Question 8 Multiple Choice (Single Answer)

The splice donor is located

  1. at the promoter
  2. at the 5' end of the intron
  3. at the branch point of the intron
  4. at the 3' end of the intron
Question 9 Multiple Choice (Single Answer)

The TATA box is located in the

  1. alternative acceptor site
  2. alternative donor site
  3. promoter
  4. intron-exon border
Question 10 Multiple Choice (Single Answer)

Which of the following types of mutation is most likely to cause premature termination of translation?

  1. Insertion of single base into DNA
  2. Deletion of three bases from DNA
  3. Deletion of an entire gene
  4. Single base change in a promoter
Question 11 Multiple Choice (Single Answer)

The anticodon sequence is found on

  1. transfer RNA
  2. messenger RNA
  3. ribosomal RNA
  4. complementary RNA (cRNA)
Question 12 Multiple Choice (Single Answer)

Pick out the CORRECT statement regarding genomic imprinting.

  1. It is a characteristic of all genes.
  2. It is associated with methylation of cytosine bases adjacent to guanosines.
  3. It occurs in females but not in males.
  4. It is reversible in somatic cells.
Question 13 Multiple Choice (Single Answer)

Which of the following statements is CORRECT regarding the antigens in ABO blood system?

  1. Individuals who have the A antigen typically would not produce the anti-A antibody.
  2. Individuals who are type AB typically produce both anti-A and anti-B antibodies.
  3. The only ABO type blood that typically does not have either A or B antigens is AB.
  4. The only ABO type blood AB is regarded as universal donor.
Question 14 Multiple Choice (Single Answer)

Doctor consulted Mr. Sinha that he is universal blood donor for the ABO system. His blood group will be

  1. A
  2. B
  3. O
  4. AB
  5. None of the above
Question 15 Multiple Choice (Single Answer)

In predetermining the phenotype for the ABO blood system

  1. blood group O is dominant at blood group A
  2. blood group B is dominant at blood group A
  3. blood type O is recessive
  4. blood type AB is recessive
Question 16 Multiple Choice (Single Answer)

Prader-Willi syndrome (PWS) can result from either an interstitial deletion involving the paternal copy of chromosome subregion 15q1-q13 or from maternal uniparental disomy of chromosome 15. The reason for this is

  1. the maternal copy of the gene(s) credited for PWS applies a dominant negative effect of the paternal allele
  2. PWS is a consequence of an anomaly of X-chromosome inactivation
  3. the paternal copy of the gene(s) responsible for PWS is imprinted and is not signified
  4. the maternal copy of the gene(s) responsible for PWS is imprinted and is not signified
Question 17 Multiple Choice (Single Answer)

Which of the following statements is CORRECT about the ABO blood system?

  1. It was discovered in the 1950's.
  2. It was discovered by Karl Landsteiner.
  3. Mostly people are literally typed for this system because of the difficulty of the procedure and high cost.
  4. The K antigen is an essential precursor to the ABO blood group antigens.
Question 18 Multiple Choice (Single Answer)

Mrs. Shukla is having Rh blood group. The greatest medical problem with the Rh blood group is

  1. chronic anemia for Rh negative ladies
  2. chronic anemia for Rh positive ladies
  3. transfusion incompatibility
  4. none of these
Question 19 Multiple Choice (Single Answer)

A person's ABO blood type is typically predetermined by

  1. genetic inheritance and environmental influences during his course of life
  2. environmental factors alone
  3. the inheritance of 1 of 3 possible alleles, i.e. either A, B or O from each of the parent
  4. combination of 2 of 3 possible alleles, i.e. either A, B or O from each of the parent
Question 20 Multiple Choice (Single Answer)

Which of the following statements is incorrrect?

  1. Specific ABO blood types are known to be associated with enhanced or declined probability to distinct human diseases.
  2. Antibodies to foreign antigens in the ABO system may be present in an individual's body previous to the first touch with blood of a variant, ABO type.
  3. When an individual's blood comes in contact with blood of a different type, his body can form indestructible immunity to the foreign blood type.
  4. All of the above statements are incorrect.
Question 21 Multiple Choice (Single Answer)

Mr. X & Mr. Y both claimed for a child in the hospital. Which of the following would be the least likely to be accepted as legal proof of paternity?

  1. ABO blood type presumption
  2. HLA typing presumption
  3. DNA sequence comparison
  4. All will be equally accepted in the court
Question 22 Multiple Choice (Single Answer)

Select the true statement about Rh positive people.

  1. They are either homozygous dominant (XX) or heterozygous (Xx) for this trait.
  2. They all are homozygous dominant (XX) individuals.
  3. They are all homozygous recessive (xx) individuals.
  4. They are either homozygous recessive (xx) or heterozygous (Xx) for this trait.
Question 23 Multiple Choice (Single Answer)

Mrs. Verma is suffering from mother-fetus Rh blood type incompatibility problems. This is happening because she is _____ and her fetus is _____ .

  1. Rh positive; Rh positive
  2. Rh positive; Rh negative
  3. Rh negative; Rh positive
  4. Rh negative; Rh negative
Question 24 Multiple Choice (Single Answer)

In a couple, if the father of the child is Rh positive and the mother is Rh negative, what are the chances that there will be erythroblastosis fetalis problem? They already had a son and the couple has taken no medical treatment to avoid this condition.

  1. 100%
  2. At least 50%
  3. Less than 50%
  4. 0%
Question 25 Multiple Choice (Single Answer)

Which of the following face the considerable danger for Rh +ve mother and her developing embryo incompatibility problems like erythroblastosis fetalis?

  1. Europeans
  2. Africans
  3. Native Americans
  4. All the peoples of the world are at equal risk
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