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Nucleotide Metabolism: Delving into the Synthesis and Breakdown of Nucleotides
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Which enzyme is responsible for the de novo synthesis of purine nucleotides?
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A
Glutamine phosphoribosyl pyrophosphate amidotransferase
💡 Explanation:
Glutamine phosphoribosyl pyrophosphate amidotransferase (GPAT) catalyzes the first step in the de novo synthesis of purine nucleotides, where glutamine donates an amino group to phosphoribosyl pyrophosphate (PRPP) to form 5-phosphoribosylamine.