Human Genetics
This test covers fundamental human genetics concepts including Mendelian inheritance, alleles, phenotypes, and blood type genetics (ABO and Rh systems), essential for medical aspirants.
Questions
Why each generation of offspring bears impregnation of maternal and paternal traits ?
- Because each cell carries same number of chromosomes.
- Because of the frequent grabbing of chromosomes by the microtubules during metaphase I
- Because of the biological composition of the chromosomes
- Because of the high frequency of viral invasion
The same base sequencing in DNA will be similar in
- a male parent and his male offspring
- identical twins
- siblings
- a female parent and her offspring
A recessive allele p is responsible for a condition called hypertonia. In a couple, male has this condition. One of their four children also has this condition. Suggest the possible genotypes of the man and woman.
- Father is Pp and mother is PP.
- Father is pp and mother is PP.
- Both parents are pp.
- Father is pp and mother is Pp
The shrinking and disorganizing of cytoskeleton are seen in the cell, which is generally
- cancerous
- ready to start mitosis
- getting engulfed by a phagocyte
- shutting down one of its X chromosomes as dosage compensation
Pick out the true statement regarding Gregor Mendel.
- His discoveries regarding genetic inheritance were eventually accepted by the scientific community in the mid 19th century.
- He concluded that genetic traits of parents will generally inherit in their offsprings.
- His postulates of gene & inheritance apply equally to plants and animals.
- His experimental plant was cross-pollinating.
Why DNA does not duplicate between meiosis I and meiosis II?
- To reduce the chromosome number to haploid in the resulting daughter cells
- To produce genetically identical daughter cells
- To increase genetic variability
- The chromosomes already duplicated twice during meiosis I.
According to Mendel, the characteristics of Pisum sativum were determined by
- inheritance of genes from both parents
- inheritance of genes from one parent only
- comparitive health of each parent plants at the time of pollination
- comparitive health of each parent plants at the time of fertilisation
An allele can be described as
- a homozygous genotype
- a heterozygous genotype
- a substitute for a gene
- one of several possible forms of a gene
The concept that different pairs of alleles are passed to progenies autonomously describes Mendel's principle of
- independent assortment
- segregation
- unit inheritance
- dominance
In an individual, phenotype expresses
- genetic makeup
- physical appearance
- a recessive allele
- genome
A persons's ABO blood type is generally determined by
- genetic factors as well as environmental factors
- environmental influences alone
- the presence of one of A, B, or O alleles inherited from the parents
- antibodies present in the blood
Which of the following is considered as the least reliable proof of paternity?
- ABO blood type evidence
- HLA type evidence
- DNA sequence evidence
- All are equally likely to be accepted
Pick the true statement regarding the ABO blood system.
- It was discovered in the 1950's.
- It was discovered by Karl Landsteiner.
- Determining ABO blood types is a difficult procedure.
- Type AB-negative is the universal donor.
Pick out the true statement regarding the antigen & antibody present in the blood, which helps in determining the blood group of the person.
- Individuals having A antigen will not produce the anti-A antibodies.
- AB types blood group individuals produce both anti-A and anti-B antibodies.
- AB type blood normally does not have either A or B antigens.
- O type blood contains both the antigens.
The severe medical problem associated with the Rh blood group is
- transfusion incompatibility
- chronic anemia for Rh negative persons
- Chronic anemia for Rh positive persons
- None of these
Select the true statements regarding the Rh blood system.
- It is the first blood system to be discovered by Landsteiner.
- It is genetically more complicated than the ABO system.
- There are 25 Rh blood types.
- It was first discovered in chimpanzee.
What conclusion is made while analysing the phenotypes of the ABO blood system?
- O is dominant over A.
- B is dominant over A.
- O is recessive to all other alleles.
- A is dominant over B.
The condition of erythroblastosis arises when the respective Rh of mother and foetus, are
- Rh positive & Rh positive
- Rh positive & Rh negative
- Rh negative & Rh positive
- Rh negative & Rh negative
Who discovered the Rh factor in humans?
- Alexander Wiener
- Karl Landsteiner
- Erwin Popper
- Constantin Levaditi
Select the true statement regarding the Rh positive people.
- They may be homozygous dominant (DD) or heterozygous (Dd) for this trait.
- They all are strictly homozygous dominant (DD) for the trait.
- They all are strictly homozygous recessive (dd).
- They may be homozygous recessive (dd) or heterozygous (Dd) for the trait.
Which of the following races is more suspected to Rh mother-foetus incompatibility problems?
- Asians
- Africans
- Native Americans
- Europeans
In a couple, male is Rh positive and the female is Rh negative, what are the chances that there will be a mother-foetus incompatibility problem? Assume that the couple has already had a child and that there has been no medical treatment to prevent this problem.
- 100%
- at least 50%
- lesser than 50%
- 0%
The medical condition where the foetus' blood is agglutinated by his own mother's Rh antibodies, is termed as
- immunization
- erythroblastosis foetalis
- ectopic pregnancy
- erythropoiesis
Mother-foetus incompatibility problems originate from
- the mother's antibodies agglutinating the embryo's Rh positive RBCs
- the embryo's antibodies agglutinating his own RBCs.
- the embryo's antibodies agglutinating his mother's RBCs.
- the mother & embryo's antibodies agglutinating each other's RBCs.
In the ABO type blood system, the universal blood donor(s) is/ are
- A
- B
- AB
- O