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Organic manure is the substance made up of animal and human excreta and plants wastes. Biofertilizer is the fertilizer made up of living or dried microorganism. Natural insecticides are the substance used to kill the harmful insect. It is made up of plant products and microorganisms. They have no negative impact on the environment. While pesticide is the synthetic substance used to kill the harmful pest. It is made of a chemical in factories. It can involve in the food chain and cause harmful effects to the environment.