Addiction and dependence - class-XII

Alcohol can cause inflammation in the liver. Over time, scarring and cirrhosis can occur. Alcoholic liver disease occurs after years of heavy drinking.
Thus, the correct answer is option (C), 'Liver'.

Alcohol can cause inflammation in the liver. Over time, scarring and
cirrhosis can occur. Alcoholic liver disease occurs after years of heavy
drinking. Cirrhosis is the last step of liver damage
So, the correct answer is 'Alcoholism'

Bhang, Ganja, and Hashish are all psychoactive products derived from the Cannabis sativa plant.

• Drug addiction is a complex neurological disease that requires integrated treatment of the mind, body, and spirit. 
• It is considered a brain disease because drugs change the brain they change its structure and how it works. Without treatment, these brain changes can be long-lasting. 
•  Addiction is chronic, it is progressive, and if left untreated, it can be fatal.

1.  Loss of control 
2. Serious changes or deterioration in hygiene or physical appearance
3. Withdrawal symptoms such as shakiness, trembling, depression, nausea and fatigue are observed.

•  Hence, The symptoms of drug addiction are restlessness, Depression and Anxiety. 
• So, the correct answer is 'all of the above'.

If a person who is having heavy dose of alcohol or drug suddenly stop or cut back on its consumption, it is called as alcohol or drug withdrawal. Mild withdrawal syndrome includes anxiety, shakiness, headache, nausea, vomiting, insomnia, sweating. The severe syndrome includes hallucination, seizures.

Abrupt discontinuation of regular does of drugs/ alcohol generates withdrawal syndrome. These are the set of symptoms which occurs due to abrupt discontinuation or dosage reduction of drug or alcohol. Withdrawal syndrome includes tremors, hallucination, vomiting, anxiety, sweating, irritability, insomnia.

Cannabinoid receptors are those receptors which are mainly present in the brain but are also present in nearly all the organs of the body. They are the receptors that are responsible for the physiological functions as well as the functioning of the body. They are primarily found in the nervous system and brain region.

Nicotine and cocaine are both stimulants that increase heart rate and blood pressure, leading to synergistic cardiovascular effects. Other combinations listed involve depressants or mixtures that do not specifically target cardiovascular enhancement as their primary interaction.

• Addiction is a psychological and physical inability to stop consuming a chemical, drug, activity, or substance.
• When a person has an addiction, and they stop taking the substance or engaging in the behaviour, they may experience symptoms. These symptoms include anxiety, irritability, tremors and shaking, nausea and vomiting, fatigue and a loss of appetite. 
• Hence, Withdrawal symptoms of drug addiction are Unpleasant symptoms shown due to non-availability of addicted drugs. 
• So, the correct answer is 'Unpleasant symptoms shown due to non-availability of addicted drugs'.

Chronic alcohol consumption interferes with the absorption and metabolism of essential nutrients, particularly B vitamins. Folic acid and vitamin B12 deficiency are common causes of megaloblastic anaemia in individuals with alcohol use disorder.

Sometimes, an addict can get a sample of heroin, which is adulterated with a dangerous poison, strychnine. Its injection is known as 'hot shot', which can cause quick death. 'hot shot' can also occur, when an addict, used to injecting heroin 3-5% purity, gets a purer blend of the  drug.
Thus, the correct answer is option (A), 'Injection'.

Excessive alcohol consumption causes chronic inflammation of the pancreas i.e. pancreatitis, which impairs its ability to secrete insulin. Insulin is a hormone necessary for maintaining the normal concentration of glucose in the blood. It promotes the conversion of glucose to glycogen i.e. glycogenesis for storage in liver and muscle cells. Deficiency of insulin raises the blood sugar glucose and may lead to insulin-dependent diabetes mellitus. Thus the correct answer is option B.

An average cup of tea contains approximately 20 - 30 mg of caffeine.

Habituation is becoming accustomed to any behaviors or condition, including psychoactive substance use. It is a desire but not a compulsion to continue taking the drug for the sense of improved well-being it engenders. This habituation is the initial stage of drug addiction,
Thus, the correct answer is option (B), 'Habituation'.

Cardiomyopathy is a disease of abnormal heart muscle. The heart becomes enlarged ann it is harder for the heart to pump and deliver blood to the rest of the body. The excessive consumption of alcohol is one of the causes of cardiomyopathy.
So, the correct answer is option C.

The consumption of methanol causes 'Toxic Optic Neuropathy' (TON). It is caused when the optic nerve is damaged by toxin which leads to visual impairment. This condition often presents as a painless, progressive, bilateral, symmetrical visual decline with variable optic nerve head damage. So, the correct answer is option C.

Laenec syndrome is Laennec cirrhosis which is a disease of the liver in which the normal lobular architecture is lost.
Fatty liver syndrome is a reversible condition wherein large vacuoles of triglyceride fat accumulate in liver cells via the process of steatosis.
Cirrhosis is a stage of scarring/fibrosis of the liver caused by many liver diseases.
Thus, the correct answer is option (D), 'All of the above'.

Nicotine is the primary addictive agent in cigarettes, chewing tobacco, cigars. Tobacco leads to nicotine dependence.
Thus, the correct answer is option (B), 'Nicotine.

Drug addiction psychological symptoms include:

• Unexplained change in personality or attitude
• Sudden mood swings, irritability, or angry outbursts
• Periods of hyperactivity, agitation or giddiness
• Lack of motivation, appears lethargic
• Appears fearful, anxious, or paranoid with no reason.

Peripheral vascular disease is commonly used to refer to peripheral artery disease, meaning narrowing or occlusion by atherosclerotic plaques of arteries outside of the heart and brain.
Risk factors for peripheral artery disease include elevated blood cholesterol, diabetes, hypertension and smoking. Complications of peripheral artery disease include sores that do not heal, ulcers, gangrene or infections in the extremities. A peripheral vascular disease that affects the veins include deep vein thrombosis, varicose veins. Pulmonary embolism is also caused by the blood clot due to peripheral vascular disease.
So, the correct answer is option D.

Tolerance is the resistance of a person when addicted to a drug and can withstand even in higher doses. Hence, the correct option is D.

Codeine is a moderately strong opiate drug that is used in pain relief and for the suppression of coughs. But strong or weak, it is still an addictive drug with many symptoms of use in common with other opiates. The road to addiction to codeine usually starts with an increasing tolerance to the drug.
Therefore, the correct answer is option B.

Alcoholism causes amnesia. The person drinks, does things and cannot remember them afterwards.

Excessive alcohol causes fatty liver or steatosis. It describes the buildup of fats in the liver. It occurs when the body creates too much fat or cannot metabolize fat fast enough. As a result, the left over is stored in the liver cells where it accumulates to become fatty liver disease.
Therefore, the correct answer is option A.

Cirrhosis is an abnormal liver condition in which there is irreversible scarring of the liver. The main causes are sustained excessive alcohol consumption and fatty liver disease. Symptoms include loss of appetite, yellowing of the skin, fluid retention (oedema) and swelling in ankles, legs and abdomen. So, the correct answer is option A.

There are 2 ways that alcohol can be processed by your liver. Most alcohol is broken down, or metabolised, by an enzyme in your liver cells known as alcohol dehydrogenase (ADH). ADH breaks down alcohol into acetaldehyde and then another enzyme, aldehyde dehydrogenase (ALDH), rapidly breaks down acetaldehyde into acetate. The acetate is further metabolised and eventually leaves your body as carbon dioxide and water.

It is advised not to drink alcohol while taking aspirin. Alcohol can increase the risk of stomach bleeding caused by aspirin.
Therefore, the correct answer is option C.

Scopolamine is an anticholinergic medicine. Scopolamine has many effects in the body including decreasing the secretion of fluids, slowing the stomach and intestines, and dilation of the pupils. Scopolamine is used to relieve nausea, vomiting, and dizziness associated with motion sickness and recovery from anesthesia and surgery. Scopolamine may also be used in the treatment of parkinsonism, spastic muscle states, irritable bowel syndrome, diverticulitis and other conditions. Scopolamine is also called as hyoscine. It is alkaloid drug obtained from a number of plants of the family Solenaceae, including nightshade (Atropa belladona), henbane and jimsonweed. 

Abuse of alcohol may cause three types of liver damage, which often develop in the following order: Accumulation of fat (fatty liver, or steatosis): This type is the least serious and can sometimes be reversed. It occurs in more than 90% of people who drink too much alcohol

Alcoholism causes amnesia. The person drinks, does things and cannot remember them afterwards.
Alcohol can cause blood glucose levels to rise or fall, depending on how much you drink.
Fatty liver syndrome results from the deposition of fats in liver cells resulting from the consumption of alcohol.
Therefore, the correct answer is option D.

Alcoholism is a condition of taking excess alcohol at a time or frequently. This addiction can lead to damage to brain (like the mood change), heart ( strokes and high blood pressure), liver ( steatosis means excessive deposition of fat in the liver and causes fatty liver), and also causes cancer like throat, mouth and liver. Thus, the correct answer is option E.

Friends can influence one to take drugs and alcohols. A person can protect himself against drug abuse by increasing ones will power to stay away from alcohol and drugs. One should not experiment with alcohol or drugs for curiosity and fun.

Adolescence is marked by accelerated physical growth, development of reproductive organs and changes in functioning of the neuroendocrine system. It is observed that during adolescence, there is generally lack of sleep due to mood swings. Lack of sleep due to mood irregulation leads to Anxiety and Depression.

During adolescence, individuals undergo a shift in social orientation where the peer group becomes the primary source of influence, identity, and social validation. While parents and teachers remain important, the peer group exerts the most significant pressure during this developmental phase.

Pharmacology is the branch of the study of drug action, in which considers the site of action of drug, toxicity, side effects on plasma half life concentration, excretory by products, etc.

 Hallucinogens cause optical illusion. Person loses all feelings of earthly existence of space and time.

Long-term alcohol abuse poses great dangers to an alcoholic's physical, mental, emotional, social and spiritual health. In addition to serious ramifications for the user's career, family and friends, alcoholism can cause irreversible damage to critical organs and body systems such as dilation of blood vessels, an increase in fat synthesis, low blood sugar and inflammation of the stomach. So, the correct answer is option C.

Cocaine is a powerful CNS( central nervous system) stimulant, which induces a sense of well-being and pleasure and delays fatigue. It causes lack of sleep, loss of appetite, headache, convulsions, insomnia, respiratory or cardiac failure and may lead to mental disorder.

Opiates are powerful painkillers and are made of opium, a white liquid in the poppy plant. Opiates produce a quick, intense feeling of pleasure followed by a sense of well-being and calm.
These include heroin, morphine, codeine, methadone, oxycontin etc.
Thus, the correct answer is option D.

Hallucinogens are drugs that generally produce dream-like state with disorientation and loss of contact with reality without any true sensory stimulus. These drugs change mood, behaviour, thoughts and perception in a manner like that of seen in psychosis. So, the correct answer is option C.

The products of hemp plant, cannabis sativa like Marijuana, Bhang, Ganja, Charas (also called as 'Hashish' in some countries like America) etc., Tetrahydrocannabinol (THC) is present in hemp plant.

Cyclosporin is used as immuno depressant, this drug is derived from a fungus Trichoderma polysporum and inhibit the activity of helper - T cells, thus help to prevent rejection of organ transplant.

Some drugs cause foetal abnormalities, when given to a pregnant women. These are called teratogens. The most well-known synthetic teratogen is thalidomide.

Mescalin, LSD and hashish are hallucinogens and they affect the regions of the brain that are responsible for coordination, thought processes, hearing and sight.
Epinephrine is a hormone and a neurotransmitter. It binds to beta-adrenergic receptors on heart muscle cells. This causes the contraction rate of the heart to increase.
Thus, the correct answer is option B.

Marijuana is a hallucinogen that causes altered perception and feeling. They have powerful mind-altering effects and can affect the regions of the brain that are responsible for co-ordination, thought processes, hearing and sight.
Thus, the correct answer is option C.

Opiates e.g., morphine, heroin, pethidine (meperidine), codeine and methadone have narcotic, analgesic, sedative and anti-stringent (that cause contraction of body parts) effects.

Catharanthus roseus, also known as the Madagascar periwinkle, is the well-known source of the anti-cancer alkaloids vincristine and vinblastine. These are secondary metabolites extracted from the plant.

Cannabis sativa is a species of plant from the family cannabaceae. It is a psychoactive drug that can be used for medicinal or recreational purpose. So, the correct option is 'marijuana'.

Alanine aminotransferase (ALT) or serum glutamate pyruvate aminotransferase (SGPT) is the enzyme produced by liver cells. It helps the body metabolize proteins. Cirrhosis is the disease in which normal liver cells are replaced by scar tissue caused by alcohol and viral hepatitis B and C. If the liver is damaged as in cirrhosis, SGPT is released into the blood and this causes SGPT levels to increase.
Thus, the correct answer is option (B), 'SGPT'.

Thromboangiitis obliterans, also called Buerger disease is a rare disease caused by small blood vessels that become inflamed and swollen. The blood vessels, then narrow or become completely blocked by the blood clots (Thrombosis). Blood vessels of the hand and feet are especially affected. This condition mostly affects young men, ages, 20-40, who are heavy smokers or chew tobacco.
Thus, the correct answer is option (A), 'Thromboangiitis obliterans'

The liver is the organ that is the most affected due to alcohol as the alcohol is processed in the liver and affects it adversely.

The endoplasmic reticulum functions as a cytoplasmic framework providing a surface for some of the biochemical activities of the for some of the biochemical activities of the cell. In the liver cells of vertegrates, smooth endoplasmic reticulum (SEF) plsys a crucial role in detoxifying many poisons and drugs.