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Blood Groups and Compatibility - Advanced
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Which of the following cells play an important role in failure of transplanted organ?
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A
$CD _4$ cells and $CD _8$ cells
💡 Explanation:
Transplant rejection is primarily a cell-mediated response. CD4+ (helper) and CD8+ (cytotoxic) T-cells recognize foreign MHC antigens on the donor organ and initiate the destruction of the graft tissue.