Questions
Which out of the following statements is incorrect?
- Genetic code is ambiguous.
- Genetic code is degenerate.
- Genetic code is universal.
- Genetic code is non-overlapping.
Choose the correct answer from the alternatives given, Human genome consists of approximately
- $3 \, \times \, 10^9$ bp
- $6 \, \times \, 10^9$ bp
- 20,000 + 25,000 bp
- $2.2 \, \times \, 10^4$ bp
Choose the correct answer from the alternatives given :
Which of the following statements regarding human genome is incorrect?
- Human genome consists of $3 \, \times \, 10^9$ bp and about 20,500 genes.
- The average gene size is 3000 bop and dystrophin is the largest known human gene.
- Chromosome 1 contains maximum (2968) number of genes and Y-chrbmosome has the least (231) number of genes.
- Repeated (or repetitive) sequences are not present in human genome.
All living organism present past and future are
- Not linked to any extent
- Linked to one another in their cell membrane
- Linked to one another by the sharing of the common genetic materials ,but to varying degrees
- Linked to another by the sharing of the common genetic material to $100\%$ extent
Which of the following is an application of human genome project?
- Understanding of phylogenetic disorder
- Improvement in gene therapy
- Understanding of mutation concept
- All of the above
The genome of Caenorhabditis elgans consists of
- 3 billion base pairs and 30,000 genes
- 180 million base pairs and 13,000 genes
- 4.7 million base pairs and 4,000 genes
- 97 million base pairs and 18,000 genes
- 12 million base pairs and 6,000 genes
Number of genes believed to be present in a human being is
- 1000
- 10,000
- 100,000
- 1,000,000
Genetic code translates the language of __________________.
- Amino acids into that of RNA
- RNA into that of protein
- Protein into that of DNA
- RNA into that of DNA
Nucleotide pairs present in human genes vary between
- 100 - 1000
- 500 - 5000
- 2000 - 2,000,000
- 10,000 - 10,000,000
Total number of base pairs found in human genome is?
- $3.5$ million
- $35000$
- $35$ billion
- $3.1$ billion
According to finding from the Human Genome Project, there are about 25000 genes but there are amny more different polypeptides. Which of the following processes might explain the discrepancy between number of genes and polypeptides?
(1) Mutations
(2) Post-translational modifications
(3) Crossing over during meiosis
(4) Alternating splicing of RNA transcripts
- 1 & 2
- 2 & $
- 1,3 & 4
- 3 & 4
The commonly used hosts in HGP ________________.
- Bacteria and yeast
- Bacteria and fungi
- Protozoa and bacteria
- Plants and fungi
Select the wrong statement.
- The human genome contains $3164.7$ million nucleotide bases
- Less than $10\%$ of the genome codes for protein
- Repeated sequences make up very large portion of the human genome
- Chromosome $1$ has most genes $(2968)$ and Y has the fewest $(231)$
The total number of nitrogenous bases in human genom is estimated to be about
- 3.5 million
- 35 thousand
- 35 million
- 3.3 billion
The most detailed genetic map is
- Cytogenetic
- Linkage
- Physical
- Sequence
Which of the following is the largest gene in humans?
- Dystrophin
- Insulin
- Titin
- Phosphofructokinase
Which of the following can improve the diagnosis of many genetic disorder?
- PCR
- Human genome project
- DNA fingerprinting
- None of the above
Which of the following is not an aim of human genome project?
- To sequence the genome of selected model organism
- Eliminate all disease
- To sequence EST fragments of cDNA in both human and mice
- To develop computational tool for analysing sequence information
Lily has .......... more DNA than human genome.
- 10 times
- 4 times
- 20 times
- 18 times
Which of the following provides fund for the human genome project?
- NIH
- DOE
- Both A and B
- NIH, DOE and ELSI
Human genome project was
discovered by
- Francis Collins and Roderick
- Watson and Crick
- Beadle and Tatum
- Paul Berg and Wollman
Human genome project was launched in
- 1980
- 1987
- 1990
- 1993
Human genome contains base pairs
- 2.5 million
- 25 million
- 27.2 million
- 3.2 billion
Human genome project was launched by
- Khorana and others
- Bhabha Institute
- U.S Department of Energy and National Institute of Health
- NASA
Number of genes present in human genome is about
- 15,000
- 21,000
- 27,000
- 30,000
A ribotide is made of
- Adenine + Deoxyribose + Phosphate
- Uracil + Ribose + Phosphate
- Thymine + Ribose + Phosphate
- Uracil + Deoxyribose + Phosphate
Which is false ?
- A/T is one
- A + G = C + T
- C/G is one
- A + T = C + G
Which ones are degenerate codons ?
- UAA, UAG and UGA
- GUA, GUG, GCA, GCG and GAA
- UUC, UUG, CCU, CAA and CUA
- UUA, UUG, CUU, CUC, CUA and CUG
- AAC, AAG, GAC and CGG
Condensation product of adenine, ribose and phosphoric acid is
- Adenylic acid
- Adenine phosphate
- Adenosine
- None of the above
Number of histone molecules in each nucleosome core is
- 14
- 12
- 10
- 8
If the codon GGU is reversed, the resulting codon will code for amino acid
- Tyr
- Trp
- Leu
- Thr
Choose the wrong statement regarding the observation drawn from Human Genome Project
- Repetitive sequences are stretches of RNA
- Less than 2% of the genome codes for protein
- Chromosome Y has the fewest number of genes
- SNPs help in tracing human history
- Repetive sequences make up a very large portion of the human genome
How many sense codons code for 20 human essential amino acids
- 61
- 62
- 63
- 64
Human genome project (HGP) was initiated in
- 1988
- 1990
- 1992
- 1994
Human genome project was started in
- $1989$
- $1990$
- $1992$
- $1995$
As per latest information human genome has
- $3,00,000$ genes
- $20,000$ genes
- $3,000$ genes
- $300$ genes
Main aim of human genome project is to
- Introduce new genes into human beings.
- Identify and sequence all the genes present in human DNA.
- Develop better techniques to compare two human DNAs.
- Remove disease causing genes from human DNA.
The state in which the viral genome gets integrated with the bacterial genome is called.
- Prophage
- Prophase
- Adsorption
- Lysogeny
The human genome contains (a) billion nucleotide bases. The average gene consists of (b) bases. Which option is correct for a & b?
- $a = 3, b = 3000$
- $a = 5, b = 3000$
- $a = 3, b = 2000$
- $a = 4, b = 3000$
All of the following except are sources of change in the genome
- Nondisjunction during meiosis
- Gene mutations
- Crossing over
- Amniocentesis
The human genome project involves all of the following except
- altering the human genome
- physical mapping of the chromosomes
- sequencing of the entire nucleotide sequence of the human genome
- location of RFLP markers
The sequencing of the entire genome (the totality of all genes) of an organism was completed in 1996. The organism was
- Human being
- Yeast
- Albino mouse
- Plasmodium vivax
The whole genome of Escherichia coli having $4.6\times 10^6$ bp will be replaced in?
- $2$ minutes
- One hour
- $40$ minutes
- $38$ minutes
Human Genome Project is under the control of Human Genome Organization which is funded primarily by
- NIH in USA
- DOE in USA
- EC in Europe
- All of the above
Human genome project was discovered by
- Francis Collins and Roderick
- Watson and Crick
- Beadle and Tatum
- Paul Berg and Wollman