Vaccination - class-XII

The first generation vaccines consist of live attenuated/ heat killed vaccines in which whole organisms in the weakened live form or heat killed form are injected. Sevcond generation vaccines are those vaccines in which the whole organism is not given. Instead of this a portion called the subunit, which may contain a protein section of the pathogen is given. Third generation vaccines are those in which recombinant techniques are used for the production of vaccines. In this technique DNA encoding the antigen is inserted into a vector which will be recognised as a pathogen in the host. Such that the host immune system generates an immune response against the vector and thereby the antigen. So, the correct answer is 'Third generation vaccines'.

According to standard immunization schedules, the second booster dose for Tetanus Toxoid (TT) and TAB is typically administered around the age of 2-3 years.

They are three types of vaccines on basis of organism or its part used as antigen.

Smallpox vaccine is produced from the artificially attenuated smallpox virus. The administration of this vaccine ios called as vaccination against smallpox. As on administration of this vaccine, our body develops immunity against the particular virus.

Recombinant DNA technology allows for the production of specific antigens without using the whole pathogen, which is the most modern and safe technique.

• Hepatitis B vaccine is a vaccine that prevents hepatitis B.
•  The first dose is recommended within 24 hours of birth with either two or three more doses given after that. 
• The vaccine is given by injection into a muscle. Serious side effects of the hepatitis B vaccine are very uncommon. Pain may occur at the site of injection.
•  The current vaccines are produced with recombinant DNA techniques.
• Hence, the Hepatitis B vaccine is Recombinant antigen vaccine.
•   So, the correct answer is 'Recombinant antigen vaccine'.

BCG stands for Bacillus Calmette Guerin, a vaccine given for protection against tuberculosis (T.B.) which is an airborne disease, caused by Mycobacterium tuberculosis.

The varicella vaccine has resulted in a decrease in the number of cases and complications from the disease. It protects about 70 to 90 percent of people from disease with a greater benefit for severe disease. Routine immunization of children is recommended in many countries. Immunization within three days of exposure may improve outcomes in children. Treatment of those infected may include calamine lotion to help with itching, keeping the fingernails short to decrease injury from scratching, and the use of paracetamol (acetaminophen) to help with fevers.

Polio vaccines are vaccines used to prevent poliomyelitis (polio). Two types are used - an inactivated poliovirus (antigen) given by injection and a weakened poliovirus (antigen) given by mouth. The inactivated polio vaccines are very safe. Mild redness or pain may occur at the site of injection. Oral polio vaccines cause vaccine-associated paralytic poliomyelitis.

DPT (also DTP and DTwP) is a class of combination vaccines against three infectious diseases in humans: diphtheria, pertussis (whooping cough), and tetanus. The vaccine components include diphtheria and tetanus toxoids and killed whole cells of the bacterium that causes pertussis (wP).
So, the correct option is "A" (Diphtheria, Wooping cough, Tetanus).

The standard immunization schedule for DPT (Diphtheria, Pertussis, Tetanus) begins with the first dose at 6 weeks of age.

Second generation vaccines were developed to reduce the risks from live vaccines. These are subunit vaccines, consisting of defined protein antigen like tetanus or diphtheria toxoid or recombinant protein components like hepatitis B surface antigen.
Therefore, the correct answer is option C.

BCG stands for Bacillus Calmette Guerin, a vaccine given for protection against tuberculosis which is an airborne disease, caused by Mycobacterium tuberculosis.  

The oral polio vaccine (OPV) was developed in 1961 by Albert Sabin. OPV consists of a mixture of live, attenuated (weakened) polio virus strains of all three polio virus types. Rotavirus liquid vaccines are also given by mouth (orally) to infants.

Triple antigen vaccine is a combination of diphtheria, tetanus and pertussis (or whooping cough). The vaccine stimulates the production of antibodies to immunize the body against the causative agents of the three viruses.

DPT (also DTP and DTwP) refers to a class of combination vaccines against three infectious diseases in humans diphtheria, pertussis (whooping cough), and tetanus. The vaccine components include diphtheria and tetanus toxoids and killed whole cells of the organism that causes pertussis (wP). 

The BCG vaccine contains a live but weakened form of a type of bacteria called Mycobacterium bovis which causes tuberculosis (TB) in cattle. The bacteria are altered so that they do not cause a TB infection, but stimulate the immune system to make resistant to the disease. The vaccine is known as BCG because a strain of the bacterium known as Bacillus Calmette-Guerin is used. 

DPT (also DTP and DTwP) refers to a class of combination vaccines against three infectious diseases in humans: diphtheria, pertussis (whooping cough), and tetanus. The vaccine components include diphtheria and tetanus toxoids and killed whole cells of the organism that causes pertussis (wP).

DPT (also DTP and DTwP) refers to a class of combination vaccines against three infectious diseases in humans: diphtheria, pertussis (whooping cough), and tetanus. The vaccine components include diphtheria and tetanus toxoids and killed whole cells of the organism that causes pertussis (wP).

Vaccines are suspensions of killed or weakened microbes or products or derivatives of micro organisms. A vaccine produces immunity to a disease by stimulating the production of antibodies.

The triple antigen vaccine is a combination of Diphtheria, Tentanus and Pertussis (DTP). This vaccine is given at the age of two months and is repeated at the age of 4 months and 6 months.
Thus, the correct answer is option B.

DPT is a class of combination vaccines which provides protection against three infectious diseases in humans i.e., diphtheria, pertussis (whooping cough), and tetanus. The components of the vaccine include diphtheria and tetanus toxoids and kill whole cells of the bacterium that causes pertussis. The usual course of childhood immunization in the USA is five doses between 2 months and 15 years. 

DPT-Hib vaccine is a combination vaccine which includes diphtheria and tetanus toxoids and whole-cell pertussis vaccine adsorbed with Hib (Haemophilus influenza - B) conjugate vaccine. It protects against the infectious diseases diphtheria, tetanus, pertussis, and Haemophilus influenza type B.

• In 1896, heat-killed phenol preserved and acetone killed lyophilized injectable whole cell S. Typhi vaccine was generated. 
• This inactivated whole-cell vaccine causes local inflammation, pain, systemic fever, malaise and disease-like symptoms.  
• Thus, the whole cell inactivated vaccine was not considered suitable for public use and in spite of being licensed it is no longer available in the market. 
• Most commonly used antibiotics for the treatment of typhoid fever are fluoroquinolones such as ciprofloxacin, ofloxacin and pefloxacin and third-generation cephalosporins such as ceftriaxone or cefotaxime. 
• Hence, Typhoid is not treated by inactivated Whole Agent Vaccine.
•  So, the correct answer is 'Typhoid'.

• Antivenom injection is an antiserum (preformed antibodies) which is obtained from the snake poison and it is transferred to the person with a snake bite. It is used to provide immediate immunity in case of emergency.
• Polio vaccines are vaccines used to prevent poliomyelitis (polio). Two types are used - an inactivated poliovirus (antigen) given by injection and an attenuated poliovirus (antigen) given by mouth. The inactivated polio vaccines are very safe. Mild redness or pain may occur at the site of injection. Oral polio vaccines cause vaccine-associated paralytic poliomyelitis.
  

A vaccine is a biological preparation that provides active acquired immunity to a particular disease. A vaccine typically contains a suspension of disease-causing microorganism and is often made from weakened (attenuated) or killed forms of the microbe, its toxins, or one of its surface proteins.  The agent stimulates the body's immune system and produces antibodies.

• Plague is an infectious disease caused by the bacterium Yersinia pestis.
•  Killed bacteria have been used since 1890 but are less effective against pneumonic plague so that recently live vaccines of an attenuated type and recombination protein vaccines have been developed to prevent the disease.
• Synthetic capsular polysaccharide vaccines are used for the treatment of pneumonia and meningitis. 
• Hence, Synthetic capsular polysaccharide material cannot be used for the preparation of vaccination against the plague. 
• So, the correct answer is 'Synthetic capsular polysaccharide material'.

Smallpox is a serious viral disorder caused by the variola virus. Variola virus is an orthopoxvirus, an enveloped DNA virus. The infection starts by exposure of the virus in the nasopharynx and characterized by fever and malaise. 

• Conjugate vaccines combine a weak antigen with a strong antigen so that the immune system has a stronger response to the weak antigen. Example: Haemophilus influenza.
•  Toxoid vaccine is made from a toxin (poison) that has been made harmless but that helps in an immune response against the toxin. They are based on the toxin produced by certain bacteria (e.g. tetanus or diphtheria). An
• The attenuated vaccine is a vaccine created by reducing the virulence of a pathogen, but still keeping it viable. Example are Measles, mumps, rubella, yellow fever. 
• Inactivated whole-cell vaccines are made from microorganisms (viruses, bacteria, other) that have been killed through physical or chemical processes. An example is Polio, bubonic plague, Hepatitis A.

Tetanus vaccine, also known as tetanus toxoid (TT), is an inactive vaccine used to prevent tetanus. A person likely to develop tetanus is immunised by giving pre-formed antibodies and it produces passive immunity. In passive immunity, the antibodies are produced in some other animals in response to given antigen. These pre-formed antibodies are then injected into the humans at the time of need or emergency.

• Tuberculosis is an infectious disease usually caused by Mycobacterium tuberculosis bacteria. Tuberculosis generally affects the lungs, but can also affect other parts of the body. The symptoms of active TB is a chronic cough with blood-containing sputum, fever, night sweats, and weight loss.

• Bacillus Calmette–Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis (TB). In most tuberculosis (TB) endemic countries, bacillus Calmette Guérin (BCG) is usually given around birth to prevent severe TB in infants.

• Hence BCG vaccine provides protection against TB.

• So, the correct answer is 'T B'.

DPT vaccine is a combination vaccine containing Diphtheria toxoid, Tetanus toxoid, and heat-killed Bordetella pertussis cells.

The smallpox vaccine protects people from smallpox by helping their bodies develop immunity to smallpox. The vaccine is made from a virus called vaccinia, which is a poxvirus similar to smallpox, but less harmful. The smallpox vaccine contains live vaccinia virus, not a killed or weakened virus like many other vaccines. For that reason, people who are vaccinated must take precautions when caring for the place on their arm where they were vaccinated, so they can prevent the vaccinia virus from spreading. The vaccine does not contain the smallpox virus and cannot give you smallpox. For most people with healthy immune systems, live virus vaccines are effective and safe. Smallpox vaccination can protect you from smallpox for about 3 to 5 years. After that time, its ability to protect you decreases. If you need long-term protection, you may need to get a booster vaccination. 

So, the correct option is 'Weakened germs'.

DPT (also DTP and DTwP) refers to a class of combination vaccines against three infectious diseases in humans diphtheria, pertussis (whooping cough), and tetanus. The vaccine components include diphtheria and tetanus toxoids and killed whole cells of the organism that causes pertussis (wP).

Explanation: The oral polio vaccine contains a live attenuated virus, that is, the live virus that is capable of multiplying but generally incapable of causing infection. The injectable polio vaccine contains the killed virus.

The complexity of the malaria parasite makes the development of a malaria vaccine a very difficult task. Vaccines are based on triggering an immune response in humans that is known to protect against an infection but there is no such response to malaria in humans.

Measles-mumps-rubella vaccine (MMR live attenuated vaccine) is not advisable during pregnancy because there is a risk to the foetus.

Explanation: Because chickenpox is airborne and is so contagious before the rash appears, it is difficult to avoid. A chickenpox vaccine is available. It is about 100 per cent effective against moderate or severe illness, and 85 or 90 per cent effective against mild chickenpox.

after having pertussis vaccine for whooping cough, infants and children had convulsions which are the involuntary contraction of muscles.