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In diabetes mellitus, either body doesn't make enough insulin, or it can't use the insulin it does produce, or a combination of both. The cells need insulin to take in the glucose and use it for energy. Since, the cells can't take in the glucose, it builds up in blood. Common symptoms include the following: frequent urination, excessive thirst, unexplained weight loss, extreme hunger, sudden vision changes, tingling or numbness in the hands or feet, feeling very tired much of the time, very dry skin, sores, that are slow to heal, more infections than usual.