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Nucleic Acids

Comprehensive quiz covering nucleic acid structures, base pairing, analogues, metabolism, and therapeutic applications.

15 Questions Published
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Questions

Question 1 Multiple Choice (Single Answer)

Which of the following nucleic acids is a 25 mer DNA antisense oligonucleotide therapeutic inhibiting insulin receptor substrate-1?

  1. MINAS
  2. Aganirsen
  3. Aminoallyl nucleotide
  4. Anti-miRNA Oligonucleotides
  5. Aptamer
Question 2 Multiple Choice (Single Answer)

Assertion (A): The G-quadruplexes are formed in nucleic acids by sequences that are rich in guanine.
Reason (R): The interaction between G5 and G21 is a 90-degree turn between the G-qudruplex and duplex motifs.

  1. A and R both are correct and R is the correct explanation of A.
  2. A and R both are correct and R is not the correct explanation of A.
  3. A is correct and R is incorrect.
  4. A is incorrect and R is correct.
  5. A and R both are incorrect.
Question 3 Multiple Choice (Single Answer)

Which of the following statements is/are false?

  1. In sequence assembly, k-mers are normally used during the construction of De Bruijn graphs.
  2. The choice of the k-mer size has many different effects on the sequence assembly.
  3. A lower k-mer size will increase the amount of edges stored in the graphs and decrease the amount of space required to store DNA sequence.
  1. Only 1
  2. Only 2
  3. Only 3
  4. Only 1 and 2
  5. Only 2 and 3
Question 4 Multiple Choice (Single Answer)

Which of the following statements is/are correct about anti-thrombin aptamers?

P. These are G-quadruplex-bearing polynucleotides.
Q. They show poor affinity and specificity against thrombin.
R. They are bound to the exosite I of thrombin majorly via their two TT loops through polar and hydrophobic interactions.

  1. Only P
  2. Only Q
  3. Only R
  4. Only P and Q
  5. Only Q and R
Question 5 Multiple Choice (Single Answer)

Which of the following identical sequences occur(s) within nucleic acid sequences, peptide sequences, protein structures and carbohydrates across different species?

  1. Conserved sequences
  2. International Nucleotide Sequence Database Collaboration
  3. Linguistic sequence complexity
  4. Sequence hypothesis
  5. Nucleic acid sequence
Question 6 Multiple Choice (Single Answer)

Which of the following is a type of oligomer molecule used in molecular biology to modify gene expression?

  1. Exosome complex
  2. Aptamer
  3. Glycol nucleic acid
  4. Aganirsen
  5. Morpholino
Question 7 Multiple Choice (Single Answer)

Which of the following is a polymer identical to DNA or RNA but differing in the composition of its backbone?

  1. Glycol nucleic acid
  2. In silico PCR
  3. Locked nucleic acid
  4. Nucleic acid analogue
  5. UCbase
Question 8 Multiple Choice (Single Answer)

Assertion (A): Purines are complementary only with pyrimidines, where pyrimidine-pyrimidine pairing is energetically unfavorable.
Reason (R): The molecules are too far apart for H-bonding to be formed.

  1. A and R both are correct and R is the correct explanation of A.
  2. A and R both are correct and R is not the correct explanation of A.
  3. A is correct and R is incorrect.
  4. A is incorrect and R is correct.
  5. A and R both are incorrect.
Question 9 Multiple Choice (Single Answer)

Assertion (A): The translation of genetic information implied in mRNA into a protein is catalysed by ribosomes.
Reason (R): Each three nucleotide codon is translated into one of twenty naturally occurring amino acids.

  1. A and R both are correct and R is the correct explanation of A.
  2. A and R both are correct and R is not the correct explanation of A.
  3. A is correct and R is incorrect.
  4. A is incorrect and R is correct.
  5. A and R both are incorrect.
Question 10 Multiple Choice (Single Answer)

Which of the following statements about nucleic acid metabolism is/are incorrect?

A. Nucleotide preparation is an anabolic mechanism involving the chemical reaction of phosphate, pentose sugar and nitrogenous base.
B. In purine synthesis, phosphoribosyl pyrophosphate is turned into inosine triphosphate.
C. Both synthesis and degradation reactions require enzymes.

  1. Only A
  2. Only B
  3. Only C
  4. Only A and B
  5. Only A and C
Question 11 Multiple Choice (Single Answer)

Which of the following exists between two nucleotides in RNA molecules that do not follow Watson-Crick base pair rules?

  1. Wobble base pair
  2. Hoogsteen base pair
  3. UCbase
  1. Only 1
  2. Only 2
  3. Only 3
  4. Only 1 and 2
  5. Only 2 and 3
Question 12 Multiple Choice (Single Answer)

Which of the following nucleic acids is a type of oligomer molecule used in molecular biology to modify gene expression?

  1. Morpholino
  2. Aganirsen
  3. Aptamer
  4. Genomic signature
  5. LY2181308
Question 13 Multiple Choice (Single Answer)

Which of the following is a synthetic alternative to the natural nucleic acids DNA and RNA as an information-storing biopolymer?

  1. Xeno nucleic acid
  2. Pluramycin A
  3. k-mer
  4. L-ribonucleic acid
  5. Aminoallyl nucleotide
Question 14 Multiple Choice (Single Answer)

Assertion (A): Most biological substrates lose their biological function when denatured.
Reason (R): The denaturing process and the associated loss of activity can be measured using techniques like dual polarisation interferometry.

  1. A and R both are correct and R is the correct explanation of A.
  2. A and R both are correct and R is not the correct explanation of A.
  3. A is correct and R is incorrect.
  4. A is incorrect and R is correct.
  5. A and R both are incorrect.
Question 15 Multiple Choice (Single Answer)

Match the following.

 
Column – I Column – II
A. Peptide nucleic acid 1. Modified RNA nucleotide synthesised by the group of Jesper Wengel
B. Locked nucleic acid 2. Artificial genetic polymer invented by Albert Eschenmoser
C. Threose nucleic acid 3. Artificially synthesised polymer similar to DNA or RNA invented by Peter E. Nielsen
  1. A - 1, B - 2, C - 3
  2. A - 3, B - 1, C - 2
  3. A - 2, B - 3, C - 1
  4. A - 2, B - 1, C - 3
  5. A - 3, B - 2, C - 1
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