Bioinorganic Chemistry

Ceruloplasmin, a glycoprotein produced in the liver, carries or transports more than 95 percent of the copper in blood plasma.

Vitamin B₁₂ (cyanocobalamin) is the only vitamin that contains a metal (cobalt).

Selenium is an important constituent of the enzyme glutathione peroxidase, which is responsible for destroying lipid-damaging peroxides.

Hemoglobin is an iron containing oxygen transport metalloprotein, which transports O₂ from the lungs to the tissues.
Myoglobin, an iron containing protein in muscle, receives oxygen from the red blood cells and transports it to the mitochondria of muscle cells.
Many enzymes vital to life contain iron, such as catalase, lipoxygenases, and IRE-BP.

Deoxy- and oxyhemoglobin have different colours. This is why the blood in our arteries (oxyhemoglobin) is brighter red than the blood in our veins (deoxyhemoglobin).

Budotitane is the drug used for cancer treatment. So, this option is correct.

 Tetrathiomolybdate is used as anti-copper agent in Wilson’s disease.

Galactose oxidase is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehydes.

Sn (Tin) is present in budotitane used to treat cancer. So, this option is correct.

Micronutrients are nutrients required by humans and other organisms throughout life in small quantities to orchestrate a range of physiological functions.
Examples: Mn, Co, Ni, Cu, Zn, V, Cr, Mo, Se, F, I, Al, Pb, Sn, Si

Urease is a nickel containing metalloenzyme of high molecular weight that catalyses the hydrolysis of urea into carbon dioxide and ammonia.
Dopamine β-hydroxylase is a copper containing enzyme that synthesises norepinephrine from dopamine.

Metalloenzymes are proteins, which function as an enzyme and contain metals. For example: Arginase containing Mn²⁺, Phosphotransferase (Mg²⁺), Cytochrome Oxidase (Cu²⁺), Alcohol dehydrogenase (Zn²⁺), etc.

Formaldehyde ferredoxin oxidoreductase is a tungsten containing metalloenzyme.

Mg is present in chlorophyll and helps in photosynthesis. It is helpful in activation of some enzymes. It also act as an information carrier.

Pernicious anemia is one of the obvious symptoms of a cobalt deficiency.

Lithium salts are widely used to treat bipolar disorder (BPD).
The square planar Pt(II) complex, cis-platin is used in chemotherapy of cancer.
Various gold compounds have been used in the treatment of rheumatoid arthritis. All are Au(I) complexes containing thiolate ligands.
Bismuth salts are used in treatment of gastritis.

Plastocyanin is a copper containing protein involved in electron transfer.
Amicyanin is a type I copper protein that plays an integral role in electron transfer.

Rubredoxin is a small iron-sulphur protein found in various sulphur-metabolising bacteria.
Rieske proteins are iron-sulphur protein components of cytochrome bc1 complexes and cytochrome b₆f complexes, which were first discovered and isolated by John S. Rieske and co-workers in 1964.
Aconitase is an iron-sulphur protein that catalyses the interconversion of citrate and isocitrate.

Wrong matching. Correct matching is given in option 1.