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Nitrogenous waste substances such as ammonia, urea and uric acid are produced during protein metabolism according to the species. Amino acids are the breakdown products of proteins in the body. Ammonia is the most toxic and requires large amount of water for its excretion. It is excreted as waste product in protozoans, e.g. amoeba, paramecium, sponges, hydra, liver fluke, earthworm, etc. Uric acid is also excreted as waste product by the most insects (e.g. cockroach), land snails (e.g. helix), land reptiles (e.g. lizards), snakes and birds.