Antimicrobial Agents (GATE)
Antimicrobial Agents: Mechanisms, classifications, and pharmacology of antibacterial, antifungal, anti-protozoal, anti-helminthic, and antiviral drugs
Questions
The representative source of all of the following antibiotics, except _________, is bacteria.
- polymyxin
- neomycin
- penicillin
- gentamicin
- chlortetracycline
Which of the following antimicrobial agents is effective against both gram-negative and gram-positive bacteria?
- Penicillin G
- Bacitracin
- Vancomycin
- Tetracycline
- Penicillin V
Which of the following antimicrobial agents is an aminoglycoside?
- Streptomycin
- Erythromycin
- Daptomycin
- Bacitracin
- Vancomycin
Which of the following is an anti-fungal polyene antibiotic?
- Miconazole
- Amphotericin B
- Terbinafine
- Flucytosine
- Clotrimazole
Match the entries:
| Column I | Column II |
| P. Bacitracin | 1. Inhibition of protein biosynthesis |
| Q. Chloramphenicol | 2. Inhibition of bacterial cell wall biosynthesis |
| R. Griseofulvin | 3. Inhibition of cell metabolism |
| S. Isoniazid | 4. Inhibition of nucleic acid biosynthesis |
- P - 1; Q - 2; R - 3; S - 4
- P - 1; Q - 3; R - 2; S - 4
- P - 2; Q - 1; R - 4; S - 3
- P - 2; Q - 3; R - 4; S - 1
- P - 3; Q - 1; R - 4; S - 2
All of the following are anti-protozoan drugs, except
- quinine
- chloroquine
- metronidazole
- quinacrine
- Albendazole
Which of the following antifungal agents acts by inhibiting cell wall synthesis?
- Terbinafine
- Miconazole
- Flucytosine
- Caspofungin
- Griseofulvin
Which of the following anti-protozoan agents inhibit(s) DNA synthesis?
- Chloroquine
- Metronidazole
- Nitazoxanide
- Only 1
- Only 2
- Only 3
- 1 and 2
- 2 and 3
Which of the following is a ureidopenicillin?
- Ampicillin
- Amoxicillin
- Azlocillin
- Carbenicillin
- Ticarcillin
The entry of HIV into the cell can be blocked by fusion inhibitors, such as
- enfuvirtide
- atazanavir
- indinavir
- saquinavir
- nevirapine
Which of the following antibiotics is an inhibitor of nucleic acid synthesis?
- Cefixime
- Ethambutol
- Vancomycin
- Clarithromycin
- Linezolid
Match the columns:
| Column I | Column II |
| P. Amphotericin B | 1. Streptomyces nodosus |
| Q. Chloramphenicol | 2. Streptomycems venezuelae |
| R. Tetracycline | 3. Streptomyces aureofaciens |
| S. Streptomycin | 4.Streptomyces griseus |
- P - 1; Q - 2; R - 3; S - 4
- P - 1; Q - 3; R - 2; S - 4
- P - 2; Q - 1; R - 4; S - 3
- P - 3; Q - 2; R - 1; S - 4
- P - 4; Q - 2; R - 3; S - 1
Which of the following is an example of glycopeptide antibiotics?
- Primaxin
- Vancomycin
- Mezlocillin
- Oxacillin
- Aureomycin
Match the columns:
| Column I | Column II |
| P. Niclosamide | 1. Inhibits absorption of nutrients |
| Q. Praziquantel | 2. Neuromuscular block |
| R. Pyantel pamoate | 3. Alters permeability of plasma membranes |
| S. Mebendazole | 4. Prevents ATP generation in mitochondria |
- P - 1; Q - 2; R - 3; S - 4
- P - 2; Q - 3; R - 4; S - 1
- P - 2; Q - 4; R - 3; S - 1
- P - 3; Q - 4; R - 2; S - 1
- P - 4; Q - 3; R - 2; S - 1
Identify the false statement.
- Cephalothin is a first-generation cephalosporin.
- Penicillin G is effective against gram-positive bacteria.
- Isoniazid inhibits incorporation of mycolic acid into cell wall of Mycobacterium spp.
- Rifampin inhibits synthesis of mRNA.
- Nalidixic acid acts by inhibiting DNA synthesis.