Immune System
Advanced immunology covering MHC molecules, hypersensitivity types, autoimmune diseases, and blood transfusion reactions
Questions
Which of the following is a class III molecule of the immune system?
Histocompatibility molecules are glycoproteins expressed at the surface of almost all vertebrate cells. The most rapid and severe rejection of foreign tissue occurs when there is a failure to properly match the donor and recipient for the major histocompatibility molecules. There are three categories of these molecules viz. I, II and III.
- Heat shock protein
- H2-K molecule
- HLA-A
- HLA-D
Which of the following is not required for IgE mediated hypersensitivity?
- IgE antibody
- Mast cell
- Neutrophil
- Antigen-presenting cell
Which of the following autoimmune diseases is characterised by an increase in WBC count and inflammation of blood vessels?
- Cogan's syndrome
- Churg-Strauss syndrome
- Erythema nodosum
- Thromboangiitis obliterans
What happens when type B blood is given to a person with type A blood?
- B Ag from the donor reacts with anti-B ab in the recipient.
- B Ag from the recipient reacts with anti-B ab in the recipient.
- B Ag from donor reacts with anti-A ab in the recipient.
- A Ag from donor reacts with anti-B ab in the recipient.
Skin lesions due to delayed hypersensitivity appear
- 48-72 hrs after second exposure
- 48-72 hrs after first exposure
- 24 hrs after first exposure
- 24 hrs after second exposure
Raynaud's phenomenon is observed in which of the following autoimmune diseases?
- Wegener's granulomatosis
- Systemic necrotizing vasculitides
- Sarcoidosis
- Diffuse scleroderma
Vasodilation in type 3 hypersensitivity is caused by
- neutrophils
- basophils
- eosinophils
- mast cells
Which of the following is an example of mismatched blood transfusion?
- Type 1 hypersensitivity
- Type 2 hypersensitivity
- Type 3 hypersensitivity
- Type 4 hypersensitivity
MHC (Major Histocompatibility Complex) class I presents the epitope in which of the following cells?
- B-cells
- Antigen-presenting cells
- Killer T-cells
- Helper T-cells
Which of the following enzymes are responsible for peptide generation in MHC-I (Major Histocompatibility Complex-I) pathway?
- Endosomal proteosomes
- Lysosomal proteosomes
- Cytosolic proteosomes
- Nuclear proteosomes
Which of the following is termed as a lack of reaction by the body's defense mechanism to foreign substances?
- Allergy
- Anergy
- Allelic exclusion
- Immune tolerance
Schaumann bodies are observed inside Langhans giant cells in which of the following autoimmune diseases?
- Sjogren's syndrome
- Sarcoidosis
- Systemic necrotizing vasculitides
- Scleroderma
Lymphoplasmacytic sclerosing pancreatitis (LPSP) pattern is seen in which of the following autoimmune diseases?
- Type 1 autoimmune pancreatitis
- Type 2 autoimmune pancreatitis
- Type 3 autoimmune pancreatitis
- Sjogren's syndrome
Which of the following pairs is incorrectly matched?
- Atopy - Immediate allergy
- Mantoux test - Delayed hypersensitivity
- Membranous nephropathy - Cytotoxic disease
- Rheumatic heart disease - Type II hypersensitivity
MHC (Major Histocompatibility Complex) class II cell surface proteins are not expressed in which of the following cells?
- Dendritic cells
- Nucleated cells
- Antigen-presenting cells
- B-cells