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Chemistry in Every Day Life
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Which one of the following is antimetabolites of bacteria?
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A
Para-Aminobenzenesulphonamide
💡 Explanation:
Para-aminobenzenesulphonamide (sulphanilamide) is a sulfa drug that acts as an antimetabolite. It competes with para-aminobenzoic acid (PABA), which bacteria need to synthesize folic acid. By mimicking PABA structure, it disrupts bacterial folate synthesis, killing the bacteria. PABA itself is not an antimetabolite - it's the metabolite bacteria actually need.