Immunity (Class XII)
Comprehensive coverage of immunity including complement system, autoimmune diseases, T-cells, macrophages, immunodeficiency disorders, and immune cell functions
Questions
Which of the following complement components is/are activated during endotoxin inactivation?
- C1 to C9
- C1 to C5
- C1, C4, C2 and C3
- C5a
Inflammation of testes is seen in which of the following autoimmune diseases?
- Opsoclonus-myoclonus syndrome
- Oophoritis
- Orchitis
- Lichen sclerosus
Which of the following statements regarding peritoneal macrophages is true?
- They are fixed macrophages.
- They are wandering macrophages.
- They are found in the bones.
- They are killer cells.
Autoimmune polyendocrine syndrome type 1 is a genetic autoimmune disorder in which multiple endocrine glands dysfunction as a result of autoimmunity. It is also known as which of the following?
- Isaac's syndrome
- POEMS syndrome
- Whitaker syndrome
- Cogan's syndrome
Which of the following T-cells call in phagocytes to destroy microbes?
- Cytotoxic T-cells
- Regulatory T-cells
- Killer T-cells
- Memory T-cells
Which of the following cells differentiate into macrophages?
- Polymorphonuclear granulocytes
- Lysosomal cells
- Monocytes
- Kuffer cells
The regulatory proteins released by activated T-cells are known as
- histamines
- monokines
- lymphokines
- antibodies
Which of the following T-cells recognise the antigens coupled to class I MHC?
- Regulatory T-cells
- Helper T-cells
- Killer T-cells
- γδ T-cells
Cyclosporin is an immunosupressive drug. In which of the following ways does it produce its action?
- Killing activated T-cells
- Inhibition of signal transduction
- Inhibiting division of immune cells
- Inhibition of complement activation
Which of the following T-cells express the CD45RO protein on their surface?
- Helper T-cells
- Memory T-cells
- Cytotoxic T-cells
- Suppressor T-cells
Behcet's syndrome is an autoimmune disease. Which of the following body organs get(s) inflamed in it?
- Myelin sheath
- Small intestine
- Blood vessels
- Eyes
Which of the following conditions occurs in immunodeficiency disease X-linked agammaglobulinemia?
- Normal number of B-cells with decreased IgG and IgA and increased IgM
- B-cells are present but with reduction in 2 or more isotypes
- Complete lack of antibodies
- Selective immunoglobulin A deficiency
Autoimmune thrombocytopenic purpura (ITP) is characterised by
- an increase in platelet count
- a decrease in platelet count
- bone marrow abnormalities
- blister formation on the skin
Which of the following is not an action of adjuvants?
- They extend the presence of antigens in the blood.
- They activate macrophages and lymphocytes.
- They accelerate the division of immune cells.
- They support the production of cytokines.
Match the columns.
| Phagocyte | Function |
| 1. NK cells | a. Present antigens |
| 2. Dendritic cells | b. Anaphylaxis |
| 3. Mast cells | c. Attack and destroy tumor cells |
| 4. Macrophages | d. Scavengers |
-
| ||
|---|---|
|1. NK cells|d. Scavengers|
|2. Dendritic cells|c. Attack and destroy tumor cells|
|3. Mast cells|a. Present antigens|
|4. Macrophages|b. Anaphylaxis| -
| ||
|---|---|
|1. NK cells|c. Attack and destroy tumor cells|
|2. Dendritic cells|a. Present antigens|
|3. Mast cells|b. Anaphylaxis|
|4. Macrophages|d. Scavengers| -
| ||
|---|---|
|1. NK cells|b. Anaphylaxis|
|2. Dendritic cells|d. Scavengers|
|3. Mast cells|a. Present antigens|
|4. Macrophages|c. Attack and destroy tumor cells| -
| ||
|---|---|
|1. NK cells|d. Scavengers|
|2. Dendritic cells|b. Anaphylaxis|
|3. Mast cells|c. Attack and destroy tumor cells|
|4. Macrophages|a. Present antigens|