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Sol-gel theory of locomotion of Amoeba is given by Hymen in 1927 and further supported by Pantin and Mast. Sol-gel theory is most accepted theory for locomotion of Amoeba. The cytoplasm present inside the cell is capable of changing into different forms, i.e. from fluid to solid and vice-versa. When the cytoplasm is in fluid state, it is known as plasmasol and when in solid or gel-like state, it is called as plasmagel. The interchange of these two states (plasmasol to plasmagel) is responsible for movement of amoeba.