Multiple choice general knowledge The most expensive hotel room in the world is Hugh Hefner Sky Villa, Palms Casino Resort, Las Vegas Ty Warner Penthouse, Four Seasons Hotel, New York Royal Penthouse Suite, President Wilson Hotel, Geneva Royal Suite, Burj Al Arab, Dubai Reveal answer Fill a bubble to check yourself C Correct answer Explanation The Royal Penthouse Suite at President Wilson Hotel in Geneva is widely regarded as the world's most expensive hotel room, costing around $80,000 per night. It offers extreme security and panoramic views of Lake Geneva.