"If you want to kill me, despise me, hate me, and live in an unsightly way... Run, and cling to life, and then some day, when you have the same eyes as I do, come before me."

This dark, manipulative challenge to hate and despise the speaker, then return when the listener has the same eyes, is quintessentially Itachi's style when confronting Sasuke. It reflects their complex brother relationship and Itachi's plan to make Sasuke stronger by driving him with hatred. Sasuke, Madara, and Obito would not deliver this specific line.