Multiple choice Which of the following is important in one-carbon metabolism and DNA synthesis? Folate Niacin Thiamin Pantothenic acid Reveal answer Fill a bubble to check yourself A Correct answer Explanation Folate coenzymes play a central role in transfer reactions of one-carbon groups, which are essential for the synthesis of purines and pyrimidines used in DNA. Without adequate folate, cell division is impaired due to the lack of DNA precursors.