Multiple choice Deficiency of which vitamin can result in macrocytic anemia? Biotin Vitamin B-12 Vitamin C Vitamin E Reveal answer Fill a bubble to check yourself B Correct answer Explanation Both vitamin B-12 and folate deficiencies impair DNA synthesis in red blood cells, leading to the formation of large, immature cells known as macrocytes. Biotin, vitamin C, and vitamin E deficiencies do not typically cause macrocytic anemia.