Multiple choice Which of these statements concerning blood platelets is not true? They extrude their nucleus as they pass through the spleen. Thrombopoietin is the major regulator of platelet production, and is produced by the liver and kidneys. The platelet lifespan is 7-10 days. The megakaryocyte matures by endomitotic synchronous replication so that the number of nuclear lobes increases within the cell. Platelet provides phospholipid for the initiation of the coagulation process. Reveal answer Fill a bubble to check yourself A Correct answer Explanation This is an incorrect statement as the platelets bud off from megakaryocytes and never have a nucleus.