Multiple choice

What is the main function of heparin?

  1. Electrostatically retains and stores histamine

  2. Regulation of cell growth and proliferation

  3. Maintenance of tissue hydration

  4. Inhibition of axonal growth

  5. Major component of synovial tissues and fluid
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A Correct answer
Explanation

Endogenous heparin is localized and stored in secretory granules of mast cells. Histamine that is present within the granules is protonated (H2A2+) at pH within granules (5.2-6.0), thus it is believed that heparin, which is highly negatively charged, functions to electrostatically retain and store histamine.[

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