Multiple choice general knowledge sports The highest ever margin of victory in the El Clasico was Real Madrd : FC Barcelona 2-6 11-1 10-5 0-10 Reveal answer Fill a bubble to check yourself B Correct answer Explanation Real Madrid's 11-1 victory over FC Barcelona in the 1943 Copa del Rey semi-final is the largest margin in El Clasico history. This match was played in very controversial circumstances during the Franco era.