Multiple choice Which of the following is a semisynthetic antibiotic? Cloxacillin Dicloxacillin Flucloxacillin Nafcillin sodium Reveal answer Fill a bubble to check yourself A Correct answer Explanation Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. It is used against staphylococci that produce beta-lactamase, due to its large R chain, which does not allow the beta-lactamases to bind.