Multiple choice

Arrange the following in correct sequence of signal transduction pathway:

  1. Hormone
  2. 7 TM receptor
  3. G protein
  4. cAMP
  5. PKA

  1. 1 → 2 → 3 → 4 → 5

  2. 1 → 3 → 2 → 4 → 5

  3. 1 → 4 → 3 → 2 → 5

  4. 5 → 2 → 3 → 4 → 1

  5. 5 → 4 → 3 → 2 → 1
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A Correct answer
Explanation

Correct answer. Correct sequence of signal transduction pathway is Hormone → 7 TM receptor → G protein → cAMP → PKA. In the G protein associated signal cascade system, binding of hormone to a cell surface receptor, like the 7TM (a 7 transmembrane alpha helices) which is a part of G protein. This will activate production of second messengers like cAMP by the enzyme adenylate cyclase. The cAMP in turn binds and activates downstream signal proteins line cAMP dependent protein kinase A (PKA).

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