Multiple choice

Which of the following statements can be excluded from the characteristics of microsatellites?

  1. Microsatellites can be amplified for identification by the polymerase chain reaction process.

  2. Random microsatellite primers can be developed by cloning random segments of DNA from the focal species.

  3. Almost 50% of the human genome is contained in various types of transposable elements.

  4. Microsatellites within introns also influence genotype.

  5. Length changes of microsatellites within promoters and other cis-regulatory regions can also change gene expression among the generations.
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D Correct answer
Explanation

Microsatellites within introns also influence phenotype. For example, a GAA triplet expansion in the first intron of the X25 gene appears to interfere with transcription, and causes Friedreich Ataxia (Bidichandani 1998).

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