Match the entries in column I (Matrices) and column II (operation).
| |
|
| Column I |
|
|
Column II |
| P. PAM |
1. Henikoff and Henikoff |
| Q. BLOSUM |
2. Margaret Dayhoff |
| R. PSSM |
3. Gary Stormo |
-
P - 1, Q - 2, R - 3
-
P - 1, Q - 3, R - 2
-
P - 3, Q - 1, R - 2
-
P - 2, Q - 3, R - 1
-
P - 2, Q - 1, R - 3
E
Correct answer
Explanation
One of the first amino acid substitution matrices, the PAM (Point Accepted Mutation) matrix was developed by Margaret Dayhoff in the 1970s.
BLOSUM matrices were first proposed by Henikoff and Henikoff for aligning protein sequences.
A position weight matrix (PWM), also known as a position-specific weight matrix (PSWM) or position-specific scoring matrix (PSSM), is a commonly used representation of motifs (patterns) in biological sequences. The position weight matrix was introduced by American geneticist Gary Stormo and colleagues in 1982 as an alternative to consensus sequences.