Multiple choice

Which of the following statements is/are TRUE?

  1. Praline is more accurate than Clustal.
  2. Alignment at the protein level is more sensitive than at the DNA level.
  3. Sequence alignment at the protein level is much more informative for functional and evolutionary analysis.

  1. Only 1

  2. Only 2

  3. Only 3

  4. All of these

  5. None of these
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

Yes, this is the correct answer. Praline is profile based and has the capacity to restrict alignment based on protein structure information, and is thus much more accurate than Clustal. Alignment at the protein level is more sensitive than at the DNA level. Sequence alignment directly at the DNA level can often result in frameshift errors because in DNA alignment gaps are introduced irrespective of codon boundaries. Sequence alignment at the protein level is much more informative for functional and evolutionary analysis.

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