Multiple choice

Cryoglobulins are immune complexes that precipitate at low temperatures. Which one of the following is the correct statement about cryoglobulins?    

  1. Samples for cryoglobulin detection must be stored on ice before they reach the laboratory.

  2. Type III cryoglobulins are associated with hepatitis C infection.

  3. Type I cryoglobulins are monoclonal proteins typically of IgA or IgD class.

  4. Cryoglobulins are always monoclonal immunoglobulins.

  5. Cryoglobulins precipitates from the blood serum in extremely hot and arid conditions.
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B Correct answer
Explanation

Type III cryoglobulins are formed through mixed complexes of polyclonal antibodies with antigen, usually in the form of large complexes; there is a strong association with hepatitis C.

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