Multiple choice

Which of the following statements is true regarding the removal of cells by apoptosis?  

  1. Auto-antigens are frequently methylated and this results directly in autoimmune sensitisation.

  2. C5 plays a central role in cellular clearance.

  3. Apoptosis can also be mediated by T cells using FAS:FAS ligand interactions.

  4. Nuclear material is expanded beneath a blebbed membrane.

  5. Macrophages secrete the pro-inflammatory cytokines IL-10 and TGFβ in response to cellular ingestion.
Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

FAS ligand (CD178) is expressed on activated T cells; the interaction with FAS, a protein on many cell types triggers enzymes to degrade the target cell DNA.

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