Multiple choice

Type IV hypersensitivity is a cell-mediated immune reaction. Which of the following is true regarding the type IV hypersensitivity?

  1. Specific antibodies are directed against cellular targets.

  2. Complement is involved.

  3. Mast cells play a central role in the effector component.

  4. Th1 cells play a central role in the effector component.

  5. Histology is typically granulomatous.
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

T cells are involved; the principle effector cells are Th1, secreting interferon-gamma and TNF, resulting in activation of macrophages. Th17 cells may also play a role.

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